Month: March 2025

As warehouses go, nuclei are more like libraries than bank vaults. Too many cellular components need access to the genome to lock it down like Fort Knox. Instead, large groupings of more than 1,000 individual protein molecules called nuclear pore complexes (NPCs) pepper the dividing membrane, serving as gateways for materials and messages entering and exiting the nucleus. While the basic need for this shuttle service is constant, scientists have shown that cells dynamically adjust their amounts of NPCs like a retail store opening more or fewer checkout lines throughout the day. Scientists now reveal the results of screening the entire human genome to find factors influencing how many NPCs are assembled.

Investigators have uncovered how resistance to chemotherapies may occur in some cancers. Researchers focused on a pathway that harnesses reactive oxygen species (ROS) to kill cancer cells. The study found that mutations to VPS35, a key player in this pathway, can prevent chemotherapy-induced cell death. These results could help pinpoint treatment-resistant tumors.

A new study found that over half of US adults experienced some form of discrimination, and individuals with high exposure to discrimination have more than five times the chances of screening positive for depression, and five times the chances of screening positive for anxiety. Compared to adults who do not experience discrimination, adults who do experience this mistreatment have nearly nine times the odds of screening positive for both depression and anxiety.

Researchers have created a way to see your family tree as a movie rather than a still portrait by tracing where your ancestors moved across the globe over time. The statistical method can also be used to model disease spread and studying how animals move through geographic regions.

New research strongly suggests that Kawasaki disease is caused by a single respiratory virus that is yet to be identified. Findings contradict the theory that many different pathogens or toxins could cause this disease that can lead to serious cardiac complications in young children.