Month: May 2025

The process of necrosis, a form of cell death, may represent one of the most promising ways to change the course of human aging, disease and even space travel, according to a new study.

New techniques used to analyze soft tissue in dinosaur fossils may hold the key to new cancer discoveries. Researchers have analyzed dinosaur fossils using advanced paleoproteomic techniques, a method that holds promise for uncovering molecular data from ancient specimens.

SAVANA uses a machine learning algorithm to identify cancer-specific structural variations and copy number aberrations in long-read DNA sequencing data. The complex structure of cancer genomes means that standard analysis tools give false-positive results, leading to erroneous clinical interpretations of tumour biology. SAVANA significantly reduces such errors. SAVANA offers rapid and reliable genomic analysis to better analyse clinical samples, thereby informing cancer diagnosis and therapeutic interventions.

Scientists have developed a data-driven method to accelerate the discovery of affordable, stable catalysts for clean hydrogen production. Using a digital platform called DigCat, they identified a low-cost metal oxide that performs both OER and HER in acidic conditions and remains stable over time.

Researchers have identified a monoacylglycerol acyltransferase-coding gene named bishu-1. It is involved in the thermal responsiveness of cool temperature-sensing neurons by regulating ionotropic receptor expression, thereby maintaining the cool temperature avoidance behaviors in Drosophila larvae.

Coffee can help you stay awake. But what does caffeine actually do to your brain once you’re asleep? Using AI, a team of researchers has an answer: it affects the brain’s ‘criticality’.

Current regulations for nanomedicines overlook the effects of the different forms of the same element, such as ions, nanoparticles, and aggregates. In a recent study, researchers developed a new analytical method combining an asymmetric flow field-flow fractionation system and mass spectrometry to separately quantify these forms. This technique allows for better quality control and safety evaluation of metal-based nanomedicines, promoting their development and clinical use, with applications also extending to food, cosmetics, and the environment.

Cohesin is a protein that forms a ring-shaped complex which wraps and alters the DNA molecule shape. It moves through the DNA and creates specific loops in the genetic material which determine the architecture of the genome and gene expression. Some mutations in the genes of the cohesion complex are responsible for rare diseases (cohesinopathies), such as the Cornelia de Lange syndrome (SCdL) or Roberts syndrome, which affect several organs and cause malformations during development.

Researchers have identified C5aR1 as a novel biomarker for metastasis risk and poor prognosis in patients with cutaneous squamous cell carcinoma (cSCC), the most common type of metastatic skin cancer. The new study’s findings in The American Journal of Pathology, published by Elsevier, found that C5aR1 promotes the invasion of cSCC tumor cells. Its elevated presence suggests that C5aR1 might serve as a useful prognostic marker for metastatic disease and, potentially, a target for future therapies in advanced cSCC.

New HIV research shows that small changes in the virus affect how quickly or slowly it replicates and how easily it can reawaken in the body. These insights bring researchers closer to finding ways to flush out the dormant virus and eliminate it for good.